In general – you should evaluate all hotfixes available, and only apply those applicable to your environment. However, some of these below I have seen impact almosteveryenvironment, and should be heavily considered.
This list is nothing official…. this is just a general list of the recommended hotfixes I end up proactively applying to most environments…. it is not a complete list of ALL hotfixes, and you may be affected by other issues.
I recommend this hotfix on all Windows Server 2012 R2 DNS servers that are monitored using the DNS management pack, or any type of monitoring which leverages the DNS PowerShell providers. The leak is caused by accessing the DNS PowerShell providers, which scripts will often call.
Config issues with Delta and Snapshot failures
If your management servers are running Windows 2012 RTM (non R2) then you MUST upgrade .NET to 4.5.1 or 4.5.2. This will resolve a problem seen in larger environments where Snapshot and Delta Config fail due to timeouts.